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Radiation Therapy

Radiation Therapy is the exciting treatment modality in which ‘rays’ (and now recently, particles also) are used to treat cancers and some benign tumors.

Types of Radiation for the Treatment of Cancer

  • These can be either Rays or Particles
  • Types of Rays used for treatment
  • High Energy X-Rays (usually, in MegaVoltage Range)
  • Gamma Rays (emanating spontaneously from radioactive elements)
  • Electrons
  • Beta Rays (similar to electrons but emanating from radioactive elements)
  • Types of Particles used for treatment
  • Protons
  • Alpha Particles
  • Carbon Ions

Mechanism of Action

You may wonder that how these magic rays are different from other rays of the electromagnetic spectrum and are used for the treatment of cancer!

These rays have a unique property by virtue of their energy that these ionize the matter or tissues through which these pass. Ionization means these rays eject electrons from the atoms and thus forming ions. These ions then cause single and double strand breaks in the DNA molecules.

The DNA molecules with double strand breaks cannot replicate during cell division and hence, the cells eventually die a ‘mitotic death’.

Particle Therapy also acts similarly, however, these differ in their dose deposition patterns in the tissues.

Modern Radiation Therapy

The technologic advancements during last century have enabled us to more precisely identify and delineate the tumor (or cancer) and very precisely directing the maximum required dose to the tumor and sparing the surrounding critical structures.

Valentis Cancer Hospital, for the first time offers state-of-the-art radiation therapy for the patients of Uttar Pradesh, Uttarakhand and nearby Haryana. The department of Radiation Oncology has most advanced linear accelerator and is now routinely employing high precision radiation therapy techniques i.e. Intensity Modulated Radiation Therapy (IMRT), Image-Guided Radiation Therapy (IGRT), Stereotactic Radiosurgery, Stereotactic Body Radiation Therapy, Frameless Radiosurgery with X-Knife (similar to Gamma Knife and CyberKnife), Electron Therapy, Volumetric Modulated Arc Therapy (VMAT) and PET-based RT and CT-MR fusion and PET-CT fusion.

The Radiation Oncology team is headed by Dr. Amit Jain who has been trained at Tata Memorial Hospital, Mumbai. He got his masters degree from Tata memorial Hospital and got extensive experience in dealing different types of cancers under his mentors Dr. K.A. Dinshaw, Dr. Rajiv Sarin, Dr. Rakesh jalali who are pioneers in the field of cancer and radiation oncology in the country. Dr. Jain also did research fellowship in Department of NeuroOncology under Dr. Jalali for treating brain tumors with Stereotactic Radiosurgery, Fractionated Stereotactic Radiation Therapy, Intensity Modulated Radiation Therapy for pediatric and adult brain tumors and arteriovenous malformations. Dr. Jain has also served as Senior Consultant in SMH-Curie Cancer Centre, Delhi and Fortis International Oncology Centre, Noida before establishing the state-of-the-art and dedicated cancer treatment facility at Valentis Cancer Hospital.

Valentis Cancer Hospital has achieved the milestone of treating 1000 patients successfully with radiation therapy recently. Valentis offers some highly sophisticated and complex treatments which are available at only few sites in the Asia as

  • Total Skin Electron Therapy (TSET) for Mycosis Fungoides
  • Total Body Irradiation (TBI) for stem cell transplant patients

HemiBody Irradiation

Stereotactic Radiosurgery for Brain Tumors as meningioma, pituitary adenoma, vestibular schwannoma, gliomas (esp in recurrent setting for glioblastoma multiforme, anaplastic astrocytoma, oligodendroglioma, pleomorphic xanthoastrocytoma, ganglioglioma, neurocytoma, etc.) craniopharyngioma, ependymoma, choroid plexus papilloma and also for brain metastases from breast, lung, renal cancers, melanomas and other cancers and arteriovenous malformations

  • Arteriovenous malformations (AVM)
  • Brain metastases
  • Chordoma
  • Gliomas
  • Acoustic neuromas
  • Cavernous angiomas
  • Intractable seizures
  • Pediatric brain tumors
  • Recurrent brain tumors
  • Pituitary adenomas
  • Meningiomas of the skull base
  • Craniopharyngiomas
  • Trigeminal Neuralgia
  • Certain functional brain disorders
IMRT and IGRT as fractionated treatment for brain tumors particularly, hippocampal sparing for preventing memory loss for glioblastoma, other gliomas and other brain tumors

Hair Sparing IMRT and IGRT for brain tumors to prevent permanent hair loss from the radiation

Hair Sparing Whole Brain Radiation Therapy for Brain Metastases

Prophylactic Cranial Irradiation as in Acute Lymphoblastic leukemia and Lymphoblastic Lymphoma Protocols and also in small cell lung cancer

IMRT and IGRT for prostate cancer and bladder cancer

Stereotactic Body Radiation Therapy for lung and liver tumors

Electron Arc Therapy for Askin Rosai tumor (Primitive Neuroectodermal Tumor of chest wall)

IMRT and IGRT for spinal tumors

Radiation Therapy for Benign Diseases e.g. for keloids, heterotopic ossification, pigmented villonodular synovitis, vertebral hemangioma

Emergencies needing urgent Radiation Therapy

Hemostatic Radiation Therapy to stop bleeding urgently from oral, cervical, bladder cancers

Spinal Cord Compression causing paralysis due to vertebral tumors or metastases, multiple myeloma

Brain Metastases

Severe Pain due to Bone Metastases or Nerve Compression by Tumors

Impending Fracture due to bone metastases

Superior Vena Cava Compression by Mediastinal Tumors, Lung Cancer